microRNA and human inducible nitric oxide synthase.
Identifieur interne : 000742 ( Main/Exploration ); précédent : 000741; suivant : 000743microRNA and human inducible nitric oxide synthase.
Auteurs : Zhong Guo [États-Unis] ; David A. Geller [États-Unis]Source :
- Vitamins and hormones [ 0083-6729 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Nitric oxide synthase type II.
- métabolisme : Monoxyde d'azote, Nitric oxide synthase type II, microARN.
- physiologie : Régulation de l'expression des gènes codant pour des enzymes.
- Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Nitric Oxide Synthase Type II.
- chemical , metabolism : MicroRNAs, Nitric Oxide, Nitric Oxide Synthase Type II.
- physiology : Gene Expression Regulation, Enzymologic.
- Humans.
Abstract
Regulation of human inducible nitric oxide synthase (iNOS) expression involves both transcriptional and posttranscriptional mechanisms. Human iNOS gene transcription is controlled in a cell type-specific manner by extracellular cytokines. Transcriptional regulation of human iNOS gene involves transcription factors NF-κB, Stat-1, AP-1, C/EBPβ, KLF6, Oct 1, and NRF. Important posttranscriptional mechanisms also regulate human iNOS mRNA stability through RNA binding proteins HuR, TTP, KSRP, and PABP. Recently, there are several miRNAs that were validated to regulate human and rodent iNOS gene expression. Among them, miR-939 and miR-26a were identified to bind with the human iNOS 3'-UTR and exert a translational blockade of human iNOS protein synthesis.
DOI: 10.1016/B978-0-12-800254-4.00002-7
PubMed: 25189382
Affiliations:
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Le document en format XML
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Geller</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 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Human iNOS gene transcription is controlled in a cell type-specific manner by extracellular cytokines. Transcriptional regulation of human iNOS gene involves transcription factors NF-κB, Stat-1, AP-1, C/EBPβ, KLF6, Oct 1, and NRF. Important posttranscriptional mechanisms also regulate human iNOS mRNA stability through RNA binding proteins HuR, TTP, KSRP, and PABP. Recently, there are several miRNAs that were validated to regulate human and rodent iNOS gene expression. Among them, miR-939 and miR-26a were identified to bind with the human iNOS 3'-UTR and exert a translational blockade of human iNOS protein synthesis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Guo, Zhong" sort="Guo, Zhong" uniqKey="Guo Z" first="Zhong" last="Guo">Zhong Guo</name></region><name sortKey="Geller, David A" sort="Geller, David A" uniqKey="Geller D" first="David A" last="Geller">David A. Geller</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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